MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報(bào),，我們不為任何個(gè)人用途提供產(chǎn)品和服務(wù),。

Amlexanox

CAS No. : 68302-57-8

MCE 國(guó)際站：Amlexanox

產(chǎn)品活性：Amlexanox (AA673; Amoxanox; CHX3673) 是特異性的 IKKε 和 TBK1 抑制劑，IC₅₀ 值為 1-2 μM。

研究領(lǐng)域：NF-κB

作用靶點(diǎn)：IKK

In Vitro: Amlexanox increases phosphorylation of TBK1 on Ser172 in 3T3-L1 adipocytes, and blocks polyinosinic:polycytidylic acid (poly I:C)-stimulated phosphorylation of interferon responsive factor-3 (IRF3), a presumed substrate of IKKε and TBK1.
Amlexanox potently inhibits the release of histamine and leukotrienes from mast cells, basophils and neutrophils in in vitro settings, possibly through increasing intracellular cyclic AMP content in inflammatory cells, a mem-brane-stabilising effect or inhibition of calcium influx.
In primary bone marrow derived macrophages (BMMs), amlexanox inhibits osteoclast formation and bone resorption. At the molecular level, amlexanox suppresses RANKL-induced activation of nuclear factor-κB (NF-κB), mitogen-activated protein kinase (MAPKs), c-Fos and NFATc1. Amlexanox decreases the expression of osteoclast-specific genes, including TRAP, MMP9, Cathepsin K and NFATc1.

In Vivo: Amlexanox (100 mg/kg, p.o.) prevents and reverses diet-induced or genetic obesity, and produces reversible weight loss in obese mice. Amlexanox also causes a significant decrease in adipose tissue mass in these mice, and an increase in circulating adiponectin. Amlexanox (25 mg/kg) significantly improves insulin sensitivity in mice with established DIO, and after four weeks of treatment, amlexanox produces marked improvements in glucose.
Amlexanox before the first application of the paste and at each has been shown to suppress both immediate and evaluation thereafter. A categorical scale is also delayed-type hypersensitivity reactions.
Amlexanox (20 mg/kg) enhances osteoblast differentiation of BMSCs. In ovariectomized (OVX) mouse model, amlexanox prevents OVX-induced bone loss by suppressing osteoclast activity.

相關(guān)產(chǎn)品：Drug Repurposing Compound Library Plus  |  FDA-Approved Drug Library Plus  |  FDA-Approved Drug Library Mini  |  Bioactive Compound Library Plus  |  Immunology/Inflammation Compound Library  |  Kinase Inhibitor Library  |  NF-κB Signaling Compound Library  |  Stem Cell Signaling Compound Library  |  FDA-Approved Drug Library  |  Anti-Aging Compound Library  |  Drug Repurposing Compound Library  |  Differentiation Inducing Compound Library  |  Anti-COVID-19 Compound Library  |  NMPA-Approved Drug Library  |  FDA Approved & Pharmacopeial Drug Library  |  Mitochondria-Targeted Compound Library  |  Targeted Diversity Library  |  Anti-Liver Cancer Compound Library   |  Human Metabolite Library  |  Anti-Prostate Cancer Compound Library  |  Withdrawn Drug Compound Library  |  Off-patent Drug Library  |  Highly Selective Inhibitors Library  |  Serine/Threonine Kinase Inhibitor Library  |  Multi-Target Compound Library  |  Mitophagy Compound Library  |  Bioactive Compound Library Max  |  Protein Kinase Compound Library  |  BAY 11-7082  |  Resveratrol  |  BX795  |  GSK8612  |  TPCA-1  |  MRT67307  |  IMD-0354  |  BMS-345541  |  IKK 16  |  BAY-985  |  MLN120B  |  Vinpocetine  |  TBK1/IKKε-IN-5  |  Tizoxanide  |  β-1,3-Glucan  |  ACHP Hydrochloride  |  Peramivir trihydrate  |  WS6  |  PS-1145  |  HOIPIN-1  |  TBK1-IN-1  |  GS143  |  SC-514  |  BAY32-5915  |  Plantainoside D  |  Abietic acid  |  BI605906

熱門產(chǎn)品線：重組蛋白  |  藥物篩選  |  天然產(chǎn)物  |  熒光染料  |  PROTAC  |  同位素標(biāo)記物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds

品牌介紹:
?   MCE (MedChemExpress) 擁有200 多種全球獨(dú)家化合物庫(kù),，我們致力于為全球科研客戶提供前沿最全的高品質(zhì)小分子活性化合物,；
?   50,000 多種高選擇性抑制劑、激動(dòng)劑涉及各熱門信號(hào)通路及疾病領(lǐng)域,；
?   產(chǎn)品種類涵蓋各種重組蛋白,，多肽，常用試劑盒 ,，更有 PROTAC,、ADC 等特色產(chǎn)品，廣泛應(yīng)用于新藥研發(fā),、生命科學(xué)等科研項(xiàng)目,；
?   提供虛擬篩選，離子通道篩選,，代謝組學(xué)分析檢測(cè)分析,，藥物篩選等專業(yè)技術(shù)服務(wù)；
?   設(shè)有專業(yè)的實(shí)驗(yàn)中心和嚴(yán)格的質(zhì)控,、驗(yàn)證體系,；
?   提供 LC/MS、NMR,、HPLC,、手性分析、元素分析等各項(xiàng)質(zhì)檢報(bào)告,，確保產(chǎn)品的高純度,、高品質(zhì)；
?   產(chǎn)品的生物活性多經(jīng)各國(guó)客戶實(shí)驗(yàn)驗(yàn)證,；
?   Nature, Cell, Science 等多種頂級(jí)期刊及制藥專利收錄了MCE客戶的科研成果,；
?   專業(yè)團(tuán)隊(duì)跟蹤最新的制藥及生命科學(xué)研究進(jìn)展，為您提供全球最新的活性化合物,；
?   與世界各大制藥公司及知名科研機(jī)構(gòu)建立了長(zhǎng)期的合作,。